SUBSEQUENT CANCER IN PATIENTS WITH EWINGS-SARCOMA

  • 1 January 1979
    • journal article
    • research article
    • Vol. 63  (11-1) , 2043-2046
Abstract
Among 31 long-term survivors of Ewing''s sarcoma, 2 patients developed 2nd primary cancers, compared to an expected rate of 0.03 (relative risk = 72; 95% confidence limit = 8-259). One patient had renal medullary neuroblastoma, which is not related to Ewing''s tumor or its therapy. The 2nd patient had a bone fibrosarcoma, arising at the primary tumor site, which was thought to be radiation-induced. The risk of radiation-induced bone sarcomas was lower, although not significantly so, than that of a recently reported series of Ewing''s tumor. These 2 reports suggest that patients with Ewing''s sarcoma have a tendency to develop radiogenic sarcomas following primary megavoltage radiation therapy. The lowest radiation dose consistent with local tumor eradication should be employed to minimize the risk of subsequent radiogenic cancer.