Use of tritium nuclear magnetic resonance for the direct location of 3H in biosynthetically-labelled penicillic acid

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Abstract
In a first application of 3H n.m.r. spectroscopy to a biosynthetic investigation, namely the incorporation of [3H]acetate by Penicillium cyclopium into penicillic acid (I), the stereospecificity of labelling of the vinyl methylene group is directly demonstrated and a biosynthetic pathway thereby proposed.