Cleft Lips and Palates in Northumberland and Durham

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Abstract
Incidence of clefts of lip and palate in Northumberland and Durham is 1.42 per 1000 live births. Cleft lip shows considerable local variations in incidence, in incidence between years, and alone differs in incidence from the only other large recent study in this country. A labile determinant for this malformation is postulated. Sex ratios suggest that complete post-alveolar cleft, but not lesser degrees of cleft palate, contains a distinctive etiological group. Variations between types of cleft in the rates of associated malformations confirm the probable, complex etiology of the group of malformations as a whole.