CONFORMATIONAL STUDIES ON SEQUENTIAL POLYPEPTIDES .7. STRUCTURAL INVESTIGATIONS ON (PRO-PHE-GLY)N AND (PHE-PRO-GLY)N

  • 1 January 1977
    • journal article
    • research article
    • Vol. 9  (5) , 310-318
Abstract
The conformational properties of (Pro-Phe-Gly)n and (Phe-Pro-Gly)n were investigated in the solid state and in solution. In solid state, X-ray diffraction patterns indicated that (Pro-Phe-Gly)n assumes a single chain triple helical structures. In solution, by circular dichroism studies, it was possible to show the existence of .beta.-bends in the presence of ethylene glycol. Similar studies carried out on (Phe-Pro-Gly)n showed no collagen or polyproline II-like structure in the solid state. In solution the .beta.-bend formation was apparent in all the solvent systems studied.

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