A ‘specificity’ pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil
- 1 May 1997
- Vol. 5 (5) , 601-612
- https://doi.org/10.1016/s0969-2126(97)00216-5
Abstract
No abstract availableKeywords
This publication has 34 references indexed in Scilit:
- Molecular cloning of testicular 20.alpha.-hydroxysteroid dehydrogenase: Identity with aldose reductaseBiochemistry, 1993
- The crystal structure of the aldose reductase.NADPH binary complex.Journal of Biological Chemistry, 1992
- An Unlikely Sugar Substrate Site in the 1.65 Å Structure of the Human Aldose Reductase Holoenzyme Implicated in Diabetic ComplicationsScience, 1992
- Novel NADPH-binding domain revealed by the crystal structure of aldose reductaseNature, 1992
- Medicinal chemistry of aldose reductase inhibitorsMedicinal Research Reviews, 1988
- Synthesis, absolute configuration and conformation of the aldose reductase inhibitor sorbinilJournal of Medicinal Chemistry, 1985
- Properties of an Aldose Reductase from Pig LensEuropean Journal of Biochemistry, 1982
- Purification and Characterization of Human‐Brain Aldose ReductaseEuropean Journal of Biochemistry, 1982
- Human Brain Aldehyde Reductases: Relationship to Succinic Semialdehyde Reductase and Aldose ReductaseJournal of Neurochemistry, 1980
- Diabetic Cataracts and FlavonoidsScience, 1977