PLASMA AND CENTRAL NERVOUS-SYSTEM KINETICS OF GAMMA-HYDROXYBUTYRATE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 25  (2) , 241-256
Abstract
Sodium gamma-hydroxybutyrate [GHB] was administered to dogs in dosages of 200-1000 mg per kg with continuous EEG and temperature monitoring. Based on these studies, pulsed doses of 500 mg/kg of GHB were given and timed serum, CSF and brain samples obtained. In addition, a group of animals were sacrificed 60 min after GHB administration and the regional distribution of GHB determined. The CSF kinetics of GHB suggests a passive diffusion of GHB into CSF but brain concentration peaked very early. Highest concentrations of GHB were found in cortical white matter with lower concentrations in subcortical areas.

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