Electron Microscopic Studies of Ichthyosis and Congenital Ichthyosiform Erythroderma

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Abstract
The ultrastructural features of the skin from patients with ichthyosis or ichthyosiform erythroderma were revealed by electron microscopy. In ichthyosis, a decrease in the numbers of mitochondria and clustered ribosomes accompanied by the diminution of keratohyalin granules was observed in the epidermal cells. In ichthyosiform erythroderma, a marked increase in the numbers of mitochondria and clustered ribosomes accompanied by the formation of extraordinarily large keratohyalin granules was observed. These results strongly suggested that the epidermal cells in ichthyosis have a lower metabolic activity and that the epidermal cells in ichthyosiform erythroderma have a higher metabolic activity and an increased rate of cell turnover. In ichthyosiform erythroderma, there were found numerous aggregates of disopganized tonofibrils within the cytoplasm of the cells in the malpighian and granular layers.

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