Amunine (Ovine CRF), Urotensin I and Sauvagine, Three Structurally-Related Peptides, Produce Selective Dilation of the Mesenteric Circulation
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 25 (2) , 116-120
- https://doi.org/10.1159/000137732
Abstract
Three synthetic peptides, urotensin I, sauvagine and ovine CRF, have > 50% sequence homology. In the dog, all three produce selective mesenteric dilation, which appears to be solely responsible for a decrease in peripheral resistance and systemic arterial blood pressure. Urotensin I and sauvagine were found to be 5–10 times more potent than CRF.This publication has 5 references indexed in Scilit:
- Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-EndorphinScience, 1981
- Action of sauvagine on the mesenteric vascular bed of the dogRegulatory Peptides, 1981
- Use of a specific mesenteric vasodilator peptide, urotensin I, to reduce afterload in the dogCanadian Journal of Physiology and Pharmacology, 1980
- ISOLATION AND AMINO-ACID-COMPOSITION OF SAUVAGINE - AN ACTIVE POLYPEPTIDE FROM METHANOL EXTRACTS OF THE SKIN OF THE SOUTH-AMERICAN FROG PHYLLOMEDUSA-SAUVAGEI1980
- DILATATION OF MESENTERIC VASCULAR BED OF DOG PRODUCED BY A PEPTIDE, UROTENSIN I1977