Effect of Treating Isolated Systolic Hypertension on the Risk of Developing Various Types and Subtypes of StrokeThe Systolic Hypertension in the Elderly Program (SHEP)
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Open Access
- 26 July 2000
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 284 (4) , 465-471
- https://doi.org/10.1001/jama.284.4.465
Abstract
The Systolic Hypertension in the Elderly Program (SHEP) was the first completed trial investigating isolated systolic hypertension. Results showed that treatment of hypertension reduced all strokes, both fatal and nonfatal, by 36%; all myocardial infarctions (MIs), both fatal and nonfatal, by 27%; all coronary heart disease by 27%; and all cardiovascular disease by 32%. Total mortality was reduced by 13%. Reductions were also demonstrated in the number of transient ischemic attacks (TIAs), and episodes of congestive heart failure.1Keywords
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