Lasonolide A: Structural Revision and Synthesis of the Unnatural (−)-Enantiomer
- 28 December 2001
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (3) , 384-385
- https://doi.org/10.1021/ja017265d
Abstract
Total synthesis of the unnatural (−)-enantiomer of lasonolide A was achieved starting from ethyl l-malate. The two tetrahydropyranyl fragments were prepared stereoselectively via radical cyclization reactions of β-alkoxyacrylates. The full structure of natural lasonolide A was determined unequivocally.Keywords
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