Susceptibility of anaerobic bacteria to Sch 34343 and other -lactam antibiotics

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Abstract
The in-vitro activity of Sch 34343 was evaluated against 381 anaerobic clinical isolates and compared with that of imipenem, cefoxitin, latamoxef (moxalactam), cefotaxime and cefoperazone. Test isolates included strains with unknown resistance to the β -lactam drugs, and two Bacreroides fragths strains that could inactivate cefoxitin. Sch 34343 and imipenem demonstrated superior activity against all the anaerobic bacteria tested, with MIC 90 s ≤1 mg/l. Sch 34343 was generally one- to two-fold more active than imipenem. Resistance to both was demonstrated by the two Bact. fragths strains that inactivated cefoxitin and by one strain of Fusobacreriwn ; these three strains were also resistant to the other drugs studied There were no other resistant strains to either Sch 34343 or irnipenem. Cefotaxime and cefopcra.zone were the least active against the Bact. fragilis group, with resistance rates of 33 and 47%, respectively. Strains resistant to cefoxitin, latamoxef, cefotaxime and cefoperazone were found among some Clostrithum spp. The Gram-positive cocci and Gram-positive bacilli were sensitive to all the drugs evaluated.

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