Effect of Vanadium Administration on Coenzyme Q Metabolism in Rats
- 1 August 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 107 (4) , 914-916
- https://doi.org/10.3181/00379727-107-26793
Abstract
Vanadium administration results in decreases in coenzyme A (CoA), coenzyme Q (CoQ), and succinoxidase activity in rat livers. Changes are similar to those in pantothenic acid (PA) deficiency and suggest a primary interference by vanadium in the metabolism of either PA or its functional form, CoA, leading to a decrease in CoQ. Simultaneous administration of calcium pantothenate, 1-cysteine hydrochloride and disodium adenosine triphosphate affords a marked protection against vanadium.Keywords
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