1-ChIoromethyl-3,5-dimethylpyrazole hydrochloride. A useful synthetic intermediate
- 1 July 1989
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 67 (7) , 1144-1147
- https://doi.org/10.1139/v89-172
Abstract
1-Chloromethyl-3,5-dimethylpyrazole hydrochloride readily undergoes nucleophilic displacement with O-, N-, or S-nu-cleophiles. 1-Phenylthiomethyl-3,5-dimethylpyrazole can be lithiated at the CH2 group and reacted with alkyl halides and carbonyl compounds. Desulfurization of the products affords a novel method of preparing N-substituted pyrazoles. Keywords: pyrazole, lithiation, chloromethylazoles, desulfurization.This publication has 0 references indexed in Scilit: