Thermodynamics of Buffered Aqueous Solutions of Various Barbiturates. Ii Effect of Buffers, Substituents and Solute Polarity
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 10 (6) , 861-871
- https://doi.org/10.3109/03639048409040786
Abstract
Solution data of ten barbiturates at three temperatures in buffered systems was abtained at pH's of undissociated solute molecules and half-neutralized pH vlaues. From these results, various thermodynamic elements could be obtained. The solubility of these compounds showed an approximately linear relationship of mole fraction and carbon number. As the number of carbon atoms of various substituents increased, the aqueous buffered solubility decreased. Additionally, the solubility of linear carbon chains is greater than branched chain substituents with diminishing differences as the carbon number is increased. Finally, the solubility of these solutes, for the most part, were unaffected by the buffer componenets.This publication has 13 references indexed in Scilit:
- The Structure-Activity Relationship in Barbiturates and Its Similarity to That in Other NarcoticsJournal of Medicinal Chemistry, 1967
- Solubility Studies on Certain BarbituratesJournal of Pharmaceutical Sciences, 1965
- Occurrence of 5-Hydroxytryptamine and 5-Hydroxytryptophan in Panaeolus sphinctrinusJournal of Pharmaceutical Sciences, 1964
- Some Physical Mechanisms in Narcosis.Chemical Reviews, 1954
- Solubility of Phenobarbital in Propylene Glycol-Alcohol-Water Systems *Journal of the American Pharmaceutical Association (Scientific ed.), 1953
- Pharmaceutical Applications of Isopropyl Alcohol. III. Solubilities of Sedatives, Hypnotics, and Sulfonamides * *Acknowledgment is made to Enjay Company, Inc, of New York for funds to carry on this study and to the various manufacturers who generously furnished the supplies of the sedatives and hypnotics used.Journal of the American Pharmaceutical Association (Scientific ed.), 1948
- Synthetic DrugsAnnual Review of Biochemistry, 1943
- THE PRESENT STATUS OF THE BARBITURATE PROBLEMPhysiological Reviews, 1939
- The use of chemical potentials as indices of toxicityProceedings of the Royal Society of London. B. Biological Sciences, 1939
- Zur Theorie der AlkoholnarkoseNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1899