Ribonuclease V of Escherichia coli : Susceptibility of Heated Ribosomal RNA and Stability of R17 Phage RNA
- 5 June 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3936) , 1225-1226
- https://doi.org/10.1126/science.168.3936.1225
Abstract
Native ribosomal RNA anid inttact pliage R17 RNA are insensitive to attack by ribonuclease V, an exonucleolytic activity associated with ribosome movement on the substrate RNA. However, ribosomal RNA becomes a substrate when it is heated under conditions that make it a template for protein synthesis, and R17 RNA is attacked if it is either heated or fragmnented. Accessibility of the 5' terminus of an RNA molecule is probably inzcreased by heating or fragmnentation and may determine its susceptibility to ribonuclease V.Keywords
This publication has 12 references indexed in Scilit:
- Ribonuclease V of Escherichia coli requires Ribosomes and is Inhibited by DrugsNature, 1970
- Polypeptide Chain Initiation: Nucleotide Sequences of the Three Ribosomal Binding Sites in Bacteriophage R17 RNANature, 1969
- Sequence of a Ribosome Binding Site in Bacteriophage Qβ-RNANature, 1969
- Sequence of the First 175 Nucleotides from the 5′ Terminus of Qβ RNA synthesized in vitroNature, 1969
- Biochemical evidence that the operator locus is distinct from the z gene in the lac operon of Escherichia coliJournal of Molecular Biology, 1969
- Nucleotide Sequence Analysis of an Enzymatically Synthesized RNA Corresponding to the 5'-Terminal Region of Q RNACold Spring Harbor Symposia on Quantitative Biology, 1969
- Nucleotide Sequences of the Ribosomal Binding Sites of Bacteriophage R17 RNACold Spring Harbor Symposia on Quantitative Biology, 1969
- New Controlling Element in the Lac Operon of E. coliNature, 1968
- Interference of bacteriophage T4 in the reproduction of RNA-phage M12Journal of Molecular Biology, 1967
- Cell-free protein synthesis programmed with R17 RNA: Identification of two phage proteinsJournal of Molecular Biology, 1966