Relation Between Blood Level of Corticoids and Their Inhibiting Effect on the Hypophyseal Stress Response
- 1 July 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 113 (3) , 616-619
- https://doi.org/10.3181/00379727-113-28442
Abstract
Summary Plasma corticosterone concentrations and adrenal corticoid production in vitro are determined in rats which have been subjected to stress at different time intervals after subcutaneous injection of a high dose of corticosterone. The inhibiting effect of this injection on the pituitary-adrenal response to stress in these rats appears not to run parallel with the induced elevation in plasma corticosterone levels. It is concluded that pituitary impairment by corticoid administration is not correlated with the existing blood level of corticoids.Keywords
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- THE EFFECT OF A LIPIDE EXTRACT FROM THE POSTERIOR HYPOTHALAMUS AND OF PITRESSIN ON THE RELEASE OF ACTH FROM THE PITUITARY GLAND1Endocrinology, 1958
- REGULATION OF PITUITARY ADRENOCORTICOTROPHIC ACTIVITY DURING THE RESPONSE OF THE RAT TO ACUTE STRESS1Endocrinology, 1947