Interaction of leucine enkephalin with (3H)naloxone binding in rat brain: Evidence for an opioid receptor complex
- 1 July 1983
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 8 (7) , 913-931
- https://doi.org/10.1007/bf00964552
Abstract
We recently presented evidence that distinct morphine and enkephalin receptors coexist in an opioid receptor complex (Mol. Pharmacol. 21:548–557, 1982). In this paper, we present data which demonstrate that in the presence of sodium leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to a crude particulate fraction of rat brain. Since the binding site labeled by [3H]naloxone in the presence of sodium may be an alternate conformation of the morphine receptor, these data provide further evidence that morphine and enkephalin receptors are allosterically coupled.Keywords
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