DOUBLE-BLIND COMPARISON OF IBUPROFEN AND PHENYLBUTAZONE IN THE SHORT-TERM TREATMENT OF RHEUMATOID ARTHRITIS

Publisher Website
Google Scholar
Abstract
A comprehensive double-blind and double-blind cross-over study of the antiphlogistic and analgesic properties of ibuprofen, 300 mg. four times daily, and phenylbutazone, 150 mg. four times daily, is described. Admitted to the trial were 108 patients with a firm diagnosis of rheumatoid arthritis according to the American Rheumatism Association criteria. The patients were divided at random into four groups; Group 1 received ibuprofen for 14 days followed by phenylbutazone for 14 days; Group 2 received the drugs in the reverse order; Group 3 had phenylbutazone for four weeks, and Group 4 ibuprofen for four weeks. Subjective and objective methods of measuring improvement were used and relevant laboratory investigations were performed. The data were mechanically processed in a computer centre. Both drugs had excellent analgesic effects, ibuprofen showed a statistically better improvement in grip strength and class of functional disability, and phenylbutazone had a favourable effect on the serum uric acid level.

This publication has 0 references indexed in Scilit: