Enantioselective synthesis of optically pure (R)- and (S)-β-lysine via nitrone cycloaddition
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 10,p. 654-655
- https://doi.org/10.1039/c39880000654
Abstract
Optically pure (R)- and (S)-β-lysines have been obtained via cycloaddition of chiral nitrone (4) to vinyl acetate, followed by facile chromatographic separation of the four resulting acetates (5) into two pairs of C-5 epimers and conversion of each pair into diastereoisomerically pure isoxazolidinone (7a or b).Keywords
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