One-pot Preparation of 1,2-Aminoalcohols or Pyrroles by CeCl3 · 7 H2O-mediated Barbier Reactions of N,N′-Bis[(S)-1-phenylethyl]ethanediimine
- 1 January 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2002 (01) , 0158-0160
- https://doi.org/10.1055/s-2002-19343
Abstract
1,2-Aminoalcohols or pyrroles were obtained from N,N’-bis[(S)-1-phenylethyl]ethanediimine by a one-pot procedure involving two Barbier additions of allylic and/or propargyl zinc reagents alternated with the hydrolysis of the unreacted imine function, followed by a cyclisation/dehydration sequence when a 1-amino-5-pentyne moiety was involved, all these steps being promoted by CeCl3·7 H2O.Keywords
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