Ifosfamide and vinorelbine: an active regimen for patients with relapsed or refractory Hodgkin's disease

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Abstract
Twenty‐six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1–4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G‐CSF support. Courses were given at 3‐week intervals.Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.