Effects of Vitamin D on Magnesium Metabolism in Rats1

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Abstract
The effect of a single dose of 5000 I U of vitamin D on the concentrations of Mg in serum and bone and the excretion of Mg in urine of vitamin D-deficient rats fed either a Mg-deficient or control diet was determined. Vitamin D treatment caused a more rapid decrease of bone and serum Mg concentrations of rats placed on a low Mg diet. Urinary Mg excretion was higher in the vitamin D-treated rats. This effect was seen in rats fed the Mg-containing control diet as well as the Mg-deficlent ration. The effect of vitamin D in increasing the renal clearance of Mg is opposite to that of parathyroid hormone. This may indicate a separate action of vitamin D on renal tubular function or an inhibition of parathyroid hormone output by vitamin D.