Renal tubular secretion of alpha ketoglutarate in dog

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Abstract
Renal uptake tubular transport, and cortical concentration of [alpha] -ketoglutarate were studied in mongrel dogs, using clearance and extraction procedures. Experiments were performed during continuous intravenous administration of citrate, [alpha]-ketoglutarate, or both, in normal acid-base balance and in acute metabolic or respiratory alkalosis. In normal acid-base balance, net reabsorption and net uptake of [alpha]-ketoglutarate occur at normal and at elevated levels of the anion. Administration of citrate, or acute alkalosis, metabolic or respiratory, depresses net reabsorption and uptake of [alpha] -ketoglutarate or converts them to net secretion and production. Under these conditions, renal cortical level of [alpha]-ketoglutarate are elevated, particularly during acute metabolic or respiratory alkalosis. These results suggest that the mechanisms whereby alkalosis influences net tubular transport of [alpha] -ketoglutarate involve, at least partially, variations in the rate of operation of the tricarboxylic acid cycle in the renal tubular epithelium.

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