The studies here reported represent a continuation and an amplification of those published by Hosoi, Alvarez and Mann.1 We wondered if we could improve intestinal absorption by dividing the food into a number of portions and giving the portions at intervals, and we thought it might be helpful to mince the food or to slow the progress of peristalsis with morphine. We wondered also what would be the effect of giving progressively larger amounts of foods. Would the efficiency of digestion fail gradually at a certain point or would it break suddenly? METHOD OF EXPERIMENTATION As was reported by Hosoi, Alvarez and Mann, the colon was removed from three dogs, and the distal end of the ileum was joined to the stump of the rectum. In this way digestion in the small intestine could be studied in animals that were free from the soiling and irritation of the skin which