CHANGES IN INTESTINAL PERMEABILITY TO LACTULOSE INDUCED BY CYTO-TOXIC CHEMOTHERAPY
- 1 January 1982
- journal article
- research article
- Vol. 66 (6) , 1435-1436
Abstract
Intestinal function during cytotoxic therapy [nitrogen mustard, vincristine, procarbazine, prednisone, cyclophosphamide] was studied in 9 patients with nonintestinal lymphoma. An early, marked and rapidly reversible increase in passive permeability, as disclosed by the lactulose test, was observed without concomitant changes in active absorption or in intestinal histology. The possibility of a toxic effect by cytotoxic drugs on intestinal intracellular junctions is discussed.This publication has 6 references indexed in Scilit:
- Cholecystokinin and Human Intestinal PermeabilityDigestion, 1980
- ABNORMAL INTESTINAL PERMEABILITY TO SUGARS IN VILLOUS ATROPHYThe Lancet, 1979
- Effect of Hyperosmolar Stimuli and Coeliac Disease on the Permeability of the Human Gastrointestinal TractClinical Science, 1978
- Increase in human intestinal permeability following ingestion of hypertonic solutions.The Journal of Physiology, 1977
- SIDE-EFFECTS OF A CYTOSTATIC TREATMENT ON GASTROINTESTINAL-TRACT1974
- Advanced Lymphosarcoma: Intensive Cyclical Combination Chemotherapy with Cyclophosphamide, Vincristine, and PrednisoneAnnals of Internal Medicine, 1972