Biochemical Changes in Spleens of Rats after Localized X-Irradiation.

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Abstract
Biochemical changes in the spleens of rats given whole body or localized irradiation (800r; 250KVP) to the exteriorized spleens were compared. Measurements of adenosine triphosphatase and 5-nucleotidase activities, desoxyribonucleic acid (DNA) concentration and citric acid synthesis were performed and the histologic appearance of the spleens was noted. It was observed that shielding the body during irradiation of the spleen prevented the large increase in the activity of phos-phatases which occurs in the spleen after whole body irradiation. Prevention of the inhibitory effect of X-radiation on citrate synthesis and a much smaller decrease in DNA content as well as less severe histologic changes were observed in the spleens of body shielded rats. The results indicated that X-radiation does not exert a direct effect on the enzymes involved in the biochemical reactions which were studied.

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