Mammary tumour induction by pituitary grafting in male mice: An animal model for male breast cancer
Open Access
- 1 January 1993
- journal article
- research article
- Published by SAGE Publications in Laboratory Animals
- Vol. 27 (4) , 358-363
- https://doi.org/10.1258/002367793780745570
Abstract
Isologous anterior pituitary grafting, 4 each, to 3-4-month-old SHN and SLN male mice resulted in an appearance of mammary tumours from 8 months of age and the incidence at 12 months reached 53·8% in each strain. All tumours were diagnosed as type B adenocarcinomas. In association with the results, normal mammary gland growth and mouse mammary tumour virus (MMTV)-gp52 antigen levels in the submaxillary glands were stimulated by the treatment in these strains. The effect of pituitary grafting was much less in GR/A male mice in which no mammary tumours appeared.Keywords
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