Betel Quid Carcinogenesis in the Baboon
- 1 January 1972
- journal article
- Published by S. Karger AG in Journal of Medical Primatology
- Vol. 1 (2) , 75-85
- https://doi.org/10.1159/000460368
Abstract
12 baboons were divided into 2 groups; 5 received the basic betel quid in a surgically-created buccal mucosal pouch, and 7 had Indian tobacco added to the quid. Calcium hydroxide, coupled with a basic protein deficiency induced in the animals, served to condition the buccal pouch mucosa. Chronic, ulcerative lesions occurred in animals on the basic quid after 30 months, yet frank malignancies were not noted histologically after 34 months of treatment. On the other hand, the betel/tobacco quid which also caused ulcerative, hemorrhagic lesions after 30 months, produced malignant invasion in 1 animal after 34 months of treatment.Keywords
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