PHYSICAL FACTORS INVOLVED IN THE ACTIVITIES OF THE MAMMALIAN KIDNEY

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Abstract
It was the purpose of the present review to give an account of those physical properties of the kidney (glomerular pressure, intrarenal pressure, leakage from the tubules, and blood flow) which appear to be important in determining urine formation in the isolated kidney, and to attempt to assess the evidence available to indicate their probable significance in the intact animal in health and disease. It was a further purpose to outline the general theory relating the chief physical properties of the kidney, to point out certain major gaps in our knowledge, and to indicate the points in the evidence which have necessitated recent changes in the theory.