Inhibition of protein synthesis by a toxic lectin from Viscum album L. (mistletoe)
- 15 September 1980
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 190 (3) , 843-845
- https://doi.org/10.1042/bj1900843
Abstract
The hemagglutinating and toxic lectin from V. labum (mistletoe) inhibits protein synthesis in a lysate of rabbit reticulocytes, with an ID50 (concentration giving 50% inhibition) of 2.6 .mu.g/ml. This effect is enhanced (ID50 0.21 .mu.g/ml) if the lectin is reduced with 2-mercaptoethanol. The lectin inhibits protein synthesis also in BL8L cells in culture. Inhibition occurs after a lag time of 3 h. The ID50 is 7 ng/ml, and increases after reduction of the lectin. This and the gross lesions observed in rats poisoned with V. album lectin indicate this is a toxin very similar to ricin.This publication has 14 references indexed in Scilit:
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