Are accessory molecules implicated in activation of T cells at the blood-retinal barrier?
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Current Eye Research
- Vol. 9 (sup1) , 131-134
- https://doi.org/10.3109/02713689008999432
Abstract
Co-culture of rat retinal pigment epithelial (RPE) cells or retinal capillary endothelial (EC) cells with T lymphocytes from immunised syngeneic rats indicated that RPE cells but not EC could process retinal S-antigen and induce antigen specific T cell activation. Activation of lymphocytes by EC however was also antigen independent, and may be due to T cell (CD2) endothelial cell (LFA-3) ligand interactions which are functional on EC but not RPE.Keywords
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