Exposure of Drosophila melanogaster embryonic cell cultures to 60‐Hz sinusoidal magnetic fields: Assessment of potential teratogenic effects

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Abstract
There is considerable concern about potential detrimental health effect associated with exposure to environmentally relevant magnetic fields. One specific concern relates to potential effects of magnetic field (MF) exposure on reproduction and development. Consequently, an in vitro teratogenesis (developmental toxicity) assay employing embryonicDrosophilacells has been used to determine whether exposure to a 60‐Hz MF of 100 μT for 16–18 hr is itself teratogenic and whether such an exposure could potentiate the teratogenic response induced by a chemical teratogen (developmental toxicant). The results demonstrated that (1) MF exposure alone did not induce a teratogenic response, whether the MF was oriented parallel or perpendicular to the plane of the culture dishes; and (2) MF exposure did not alter the teratogenic response induced by optimal or suboptimal concentrations of three chemical teratogens (retinoic acid, hydroxyurea, and cadmium). Furthermore, in additional studies, Drosophilaembryos were exposed to 60‐Hz MFs of 10 and 100 μT for 24 hr or for their entire development time (i.e., until adult ecolsion, about 10 days). Results demonstrated that MF exposure did not produce an increase in developmental abnormalities over those observed in unexposed controls.