The common biology of cancer and ageing
Top Cited Papers
- 16 August 2007
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 448 (7155) , 767-774
- https://doi.org/10.1038/nature05985
Abstract
At first glance, cancer and ageing would seem to be unlikely bedfellows. Yet the origins for this improbable union can actually be traced back to a sequence of tragic—and some say unethical—events that unfolded more than half a century ago. Here we review the series of key observations that has led to a complex but growing convergence between our understanding of the biology of ageing and the mechanisms that underlie cancer.Keywords
This publication has 100 references indexed in Scilit:
- The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cellsGenes & Development, 2007
- Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasNature, 2007
- Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationNature, 2006
- Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsNature, 2006
- Oncogene-Induced Cell Senescence — Halting on the Road to CancerNew England Journal of Medicine, 2006
- The power and the promise of oncogene-induced senescence markersNature Reviews Cancer, 2006
- The serial cultivation of human diploid cell strainsPublished by Elsevier ,2004
- Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsProceedings of the National Academy of Sciences, 1996
- Regulation of p16CDKN2 Expression and Its Implications for Cell Immortalization and SenescenceMolecular and Cellular Biology, 1996
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Nature, 1993