RESPONSE OF CONVENTIONALLY RAISED WEANLING PIGS TO EXPERIMENTAL-INFECTION WITH A VIRULENT-STRAIN OF PORCINE PARVOVIRUS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (8) , 1221-1224
Abstract
Conventionally raised 6 wk old pigs were inoculated intranasally and orally with porcine parvovirus. The pigs remained clinically normal for up to 17 days. They were viremic 2-6 days after inoculation and had detectable hemagglutination-inhibiting titers to porcine parvovirus at 5 or 6 days after inoculation. Virus was isolated from multiple tissues of pigs killed 3-17 days after inoculation. Viral antigen was demonstrated mainly in lymphoid tissues of these pigs. Gross and microscopic examination of tissues failed to reveal any notable pathologic changes. The numbers of T- and B-lymphocytes did not differ significantly in inoculated and noninoculated control pigs and the response of peripheral blood lymphocytes to selected mitogens was not altered by infection.