Transient Abnormal Myelopoiesis and Diffuse Hepatic Necrosis in Down's Syndrome with Prominent Bleeding Diathesis
- 1 February 1990
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 79 (2) , 241-244
- https://doi.org/10.1111/j.1651-2227.1990.tb11449.x
Abstract
The first case known to us with Down's syndrome with transient abnormal myelopoiesis and diffuse hepatic necrosis is reported. The infant had prominent bleeding diathesis and hepatosplenomegaly. She died on the 7th day because of intractable bleeding. The autopsy disclosed extramedullary hematopoiesis and extensive hepatic cell necrosis. Characteristic in our case was the outstanding bleeding diathesis due to coagulopathy.Keywords
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