Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease
- 13 April 2004
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 62 (7) , 1224-1226
- https://doi.org/10.1212/01.wnl.0000118281.66802.81
Abstract
The authors studied whether olfactory dysfunction is present in parkin disease using the University of Pennsylvania Smell Identification Test (UPSIT). The mean UPSIT score in parkin patients was 27.3 (95% CI 24.4 to 30.2). This did not differ from the normal group mean of 29.4 (95% CI 28.0 to 30.7; p = 0.22) but was higher than the Parkinson disease group (mean 14.3; 95% CI 12.2 to 19.5; p < 0.0001) and the parkin-negative group (mean 17.1; 95% CI 14.8 to 16.3; p < 0.0001) values. Parkin disease may be a distinct and separate entity from Parkinson disease.Keywords
This publication has 10 references indexed in Scilit:
- Parkin disease: a phenotypic study of a large case seriesBrain, 2003
- Olfaction in neurodegenerative disorderMovement Disorders, 2003
- Progression of nigrostriatal dysfunction in a parkin kindred: an [18F]dopa PET and clinical studyBrain, 2002
- Genetics of Parkinson's disease and biochemical studies of implicated gene productsCurrent Opinion in Genetics & Development, 2002
- Recent advances in the genetics and pathogenesis of Parkinson diseaseNeurology, 2002
- Olfactory identification is impaired in clinic‐based patients with vascular dementia and senile dementia of Alzheimer typeInternational Journal of Geriatric Psychiatry, 2001
- An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in theparkin geneMovement Disorders, 2000
- Association between Early-Onset Parkinson's Disease and Mutations in theParkinGeneNew England Journal of Medicine, 2000
- Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6qNeurology, 1998
- The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.Journal of Neurology, Neurosurgery & Psychiatry, 1988