Renal Function Related to Acutely and Chronically Raised Intra-Abdominal Pressure in Anesthetized and Unanesthetized Dogs

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Abstract
Increasing intra-abdominal pressure by 10 mm. Hg has no significant effect on glomerular filtration (GF) or on renal plasma flow (RPF). When pressure is raised to 20 mm. Hg, both GF and RPF are diminished 50%. At 30 mm. Hg, however, no further significant reduction of GF or of RPF occurs, but at 40 mm. Hg there is reduction of both to 28% of normal. Non-protein N rises when intra-abdominal pressure is increased on the same general order of that following nephrectomy when there was no increase in the intra-abdominal pressure. Chronic studies show failure of unanesthetized animals to withstand sudden increase in intra-abdominal pressure as animals die in shock, but raising the pressure slowly over a period of weeks allows for "adjustment," which can be seen in normal phenolsulfonphthalein (PSP) and urinary output. Following absorption of air, sudden re-inflation results in marked retention of urine. In animals whose intra-abdominal pressure was raised and carefully maintained for months at high levels there was seen a gradual increase in blood NPN and a decrease in urinary sp. gr. Blood pressure (mean) was elevated from 20 to 30 mm. Hg for 2-8 weeks following inflation, but tended to retreat toward normal as inflation was maintained.

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