Evidence for 16β-hydroxylation of estrogens by guinea pig liver slices
- 1 July 1977
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 55 (7) , 769-771
- https://doi.org/10.1139/o77-111
Abstract
In an earlier communication, it was shown that estrone-3-sulfate could be hydroxylated in the 16.alpha. position by guinea pig liver slices. Disulfates of 16.alpha.-hydroxyestrone and estriol were identified. Suggestive evidence for 6-hydroxylated metabolites was mentioned. A careful reinvestigation showed that the steroid disulfate fraction is composed of 16.alpha.- and 16.beta.-hydroxylated steroids. 16.beta.-Hydroxyestrone in particular is an important quantitative metabolite of estradiol-17.beta.. No firm evidence is available for the formation of 6-hydroxysteroids in this tissue system.This publication has 3 references indexed in Scilit:
- In vitro and in vivo studies on the metabolism of estrogens and their sulfates in guinea pigsCanadian Journal of Biochemistry, 1977
- The metabolism of estriol in the guinea-pigThe Journal of Steroid Biochemistry and Molecular Biology, 1976
- The isolation of 6-α-hydroxyoestrone from the urine of pregnant womenBiochemical Journal, 1966