POLY‐N‐ACRYLYLPYRROLIDINE A NEW RESIN IN PEPTIDE CHEMISTRY
- 1 February 1979
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 13 (2) , 109-112
- https://doi.org/10.1111/j.1399-3011.1979.tb01857.x
Abstract
Entirely beaded poly-N-acrylylpyrrolidine-co-bisacrylyl-1, 2-diaminoethane-co-N-acrylyl-1, 6-diaminohexane-HCl(PAP), a new resin on which to perform peptide chemistry, has been prepared by reverse phase suspension polymerization in quantitative yield. In addition to being a superior support to polystyrene, albeit readily adaptable to current techniques of peptide synthesis, its versatility has been further extended by the introduction and use of new peptide-to-polymer linking groups, which allow the use of the bidirectional approach to peptide chemistry. One such linkage, which connects the side chain of cysteine to PAP via an acid resistant S-carbamoyl bond, was used in a bidirectional synthesis of deamino-oxytocin. PAP solvates and swells in solvents with wide-ranging polarities, including aqueous media. Thus, peptide coupling reactions were performed in organic media of high and of low polarity as well as in aqueous solution.Keywords
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