Retention Behavior of Some Ring-Substituted Aniline Derivatives on Polyethylene-Coated and Octadecylsilica Columns

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Abstract
The retention characteristics of 16 aniline derivatives were determined on polyethylene-coated and on octa-decylsilica columns in methanol- 25 mM K2HPO4 mixtures at various organic phase concentrations. Good linear correlations were found on both column between logk' values and the organic mobile phase concentration in the eluent. Stepwise regression analysis proved that not only lipo-philicity but electronic parameters of aniline derivatives have significant influence on the retention of aniline derivatives on polyethylene-coated silica column. Principal component analysis indicated that the retention behaviour of PEE column slightly differs from that of ODS column. This discrepancy is probably due to the hydrophobic interactions between the polar substructures of aniline derivatives and the free silanol groups not-covered by polyethylene.