Do inducers of apoptosis trigger caspase-independent cell death?
- 15 February 2005
- journal article
- opinion
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 6 (3) , 268-275
- https://doi.org/10.1038/nrm1573
Abstract
Apoptotic cell death is mediated by molecular pathways that culminate in the activation of a family of cysteine proteases, known as the caspases, which orchestrate the dismantling and clearance of the dying cell. However, mounting evidence indicates that a cell that has been treated with an apoptotic inducer can also initiate a suicide programme that does not rely on caspase activation. Here, we present recent findings and discuss the physiological relevance of caspase-independent cell death.Keywords
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