Clofibrate in Perspective

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Abstract
AN intensive search for a safe and effective means of reducing serum lipid and lipoprotein levels has been precipitated by the vast body of evidence that the risk of developing premature vascular disease is a function of serum cholesterol and low-density lipoprotein concentrations. Dietary restriction of saturated fats and cholesterol and substitution of polyunsaturated for saturated fats may be a useful therapeutic tool for reducing serum cholesterol levels in selected cases. Dietary therapy has also been reported, in recent incompletely controlled studies, to produce a decrease in incidence of new clinical episodes of myocardial infarction in patients with pre-existent ischemic . . .