Effect of Dietary Phosphorus Levels on Porcine Renal 25-Hydroxyvitamin D-1α- and 24R-Hydroxylase Activities and Plasma 1,25-Dihydroxyvitamin D3 Concentration1

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Abstract
Results of studies on the effect of dietary P deprivation on pig renal lα- and 24-hydroxylase activities and on concentrations of plasma alkaline phosphatase, Ca, P and vitamin D metabolites are presented. Renal lα-hydroxylase activity was increased six- to eightfold and plasma 1,25-dihydroxyvitamin D3 concentration increased two- to threefold in pigs fed a low P diet (.085% P) compared with pigs fed a control diet (.6% P). In contrast, renal 24-hydroxylase activity and plasma 25-hydroxy-vitamin D concentration did not differ between diet groups. Plasma alkaline phosphatase activity was two to four times higher in pigs fed the low P diet compared with pigs fed the control diet. The rate of gain by pigs fed the low P diet was less than pigs fed the control diet. The low P diet was associated with a prolonged elevation of renal lα-hydroxylase activity in spite of the presence of a pronounced hypercalcemia. Copyright © 1985. American Society of Animal Science . Copyright 1985 by American Society of Animal Science

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