Propofol and fentanyl anaesthesia for patients with low cardiac output state undergoing cardiac surgery: comparison with high-dose fentanyl anaesthesia
Open Access
- 1 August 1994
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 73 (2) , 162-166
- https://doi.org/10.1093/bja/73.2.162
Abstract
We have compared the haemodynamic effects of an infusion of propofol 8mg kg−1 h−1 followed by 4mg kg−1h−1 and fentanyl 15μg kg−1 (group 1) with midazolam 3–6mg and fentanyl 60 μg kg−1 (group 2) in patients with a low cardiac output state undergoing cardiac surgery. Heart rate was lower in group 1 throughout the period before cardiopulmonary bypass. There were no significant differences between the groups in other measured variables. Arterial pressure decreased in both groups after induction, by 21% in group 1 and 18% in group 2. Thermodilution assessment of right ventricular ejection fraction was unchanged. Myocardial contractility was not affected adversely. Patients in group 1 who received an infusion of propofol and a smaller dose of fentanyl awakened sooner and the trachea was extubated earlier.Keywords
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