Molecular Steps of Tumor Necrosis Factor Receptor-Mediated Apoptosis
- 1 July 2001
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Molecular Medicine
- Vol. 1 (3) , 317-324
- https://doi.org/10.2174/1566524013363780
Abstract
Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced apoptosis. A role of RIP is emphasized and novel mechanisms of FLIP-mediated inhibition of apoptosis are discussed. In addition, various mechanisms of TNF-induced activation of mitochondrial pathway of apoptosis have been reviewed.Keywords
This publication has 0 references indexed in Scilit: