Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents
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- 8 February 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 5 (3) , 473-477
- https://doi.org/10.1021/nl047950t
Abstract
Gold nanocages of 4 in an aqueous solution. By controlling the molar ratio between Ag and HAuCl4, the gold nanocages could be tuned to display surface plasmon resonance peaks around 800 nm, a wavelength commonly used in optical coherence tomography (OCT) imaging. OCT measurements on phantom samples indicate that these gold nanocages have a moderate scattering cross-section of ∼8.10 × 10-16 m2 but a very large absorption cross-section of ∼7.26 × 10-15 m2, suggesting their potential use as a new class of contrast agents for optical imaging. When bioconjugated with antibodies, the gold nanocages have also been demonstrated for specific targeting of breast cancer cells.Keywords
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