Polyoma Virus and L Cell Relationship. II. A Curable Carrier System not Dependent on Interferon2

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Abstract
The persistent infection of strain L cells with polyoma virus can be characterized as follows: 1) A high proportion of cells may carry complete, infectious virus in their cytoplasm without obvious cytopathology and may enter and complete mitosis; 2) a low percentage of cells (<1–3%) enter a cytolytic cycle; 3) the infection can be cured by the cultivation of infected cells for a prolonged period in specific antiserum; 4) interferon is not responsible for the protection of exposed cells from the cytolytic effect of polyoma virus; and 5) a state of autologous interference may provide some protection for potentially susceptible cells.