Isoflurane Does Not Increase the Rate of CSF Production in the Dog

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Abstract
Using the open ventriculocisternal perfusion method, the rate of CSF production was examined in dogs anesthetized with isoflurane (1.4%) and N2O (65%) in O2. In group 1 (n = 6), the rate of CSF production did not change significantly when the expired concentration was decreased from 1.4% to < 0.15%. In group 2 (n = 6) maintained at isoflurane 1.4%, the rate of CSF production decreased by .apprx. 8%/h, similar to the time effect previously reported in controls with this model (a decrease of 4-9%/h). Apparently, isoflurane causes no significant change in the rate of CSF production and an increase in CSF volume doses not occur during prolonged isoflurane anesthesia. In patients at risk due to increased intracranial pressure, isoflurane may be preferred to anesthetics that may increase intracranial volume, e.g., enflurane or ketamine.