Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction
- 29 February 1996
- journal article
- review article
- Published by The Royal Society in Philosophical Transactions Of The Royal Society B-Biological Sciences
- Vol. 351 (1336) , 151-157
- https://doi.org/10.1098/rstb.1996.0011
Abstract
The inflammatory cytokines interleukin 1 (IL1) and tumor necrosis factor (TNF) have a broad range of physiological effects. Whereas their immediate post-receptor events are not well understood, both have the potential to activate a range of protein kinases. These include the three types of mitogen activated protein (MAP) kinase (ERK, JNK/p54 and p38) and a $\beta $-casein kinase. The mechanisms by which these kinases are activated is discussed and the significance of their activation for particular biological responses is assessed.Keywords
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