A STUDY OF THE BEHAVIOR OF FOWL POX VIRUS MODIFIED BY INTRACEREBRAL PASSAGE
Open Access
- 1 June 1938
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 67 (6) , 933-940
- https://doi.org/10.1084/jem.67.6.933
Abstract
The author observed the pathology produced by fowl pox virus that had been modified by intracerebral passage and found that there was a marked change in its behavior both in the chorioallantoic membrane of the chick embryo and in the skin of baby chicks. These changes consisted of a great and persistent increase in virulence for epithelial cells, characterized by rapid necrosis instead of proliferation and hyperplasia, an affinity for cells of mesodermal origin including endothelial cells of blood vessels, and an increase in affinity for entodermal cells. One intracerebral passage was sufficient to produce this change in the virus.This publication has 4 references indexed in Scilit:
- A MENINGO-ENCEPHALITIS IN CHICKS PRODUCED BY THE INTRACEREBRAL INJECTION OF FOWL POX VIRUSThe Journal of Experimental Medicine, 1938
- Comparison of the behavior of a neurotesticular and a dermal strain of vaccine virus in the chorio-allantoic membrane of the chick embryo1936
- THE PREPARATION OF ANTISMALLPOX VACCINE BY CULTURE OP THE VIRUS IN THE CHORIOALLANTOIC MEMBRANE OP CHICK EMBRYOS, AND ITS USE IN HUMAN IMMUNIZATION*American Journal of Epidemiology, 1935
- The susceptibility of the chorio-allantoic membrane of chick embryos to infection with the fowl-pox virus1931